Abstract Search

ey0015.3-4 | Mechanisms of the year | ESPEYB15

3.4 Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

GS Hones , H Rakov , J Logan , XH Liao , E Werbenko , AS Pollard , SM Praestholm , MS Siersbaek , E Rijntjes , J Gassen , S Latteyer , K Engels , KH Strucksberg , P Kleinbongard , D Zwanziger , J Rozman , V Gailus-Durner , H Fuchs , M Hrabe de Angelis , L Klein-Hitpass , J Kohrle , DL Armstrong , L Grontved , JHD Bassett , GR Williams , S Refetoff , D Fuhrer , LC Moeller

To read the full abstract: Proc Natl Acad Sci U S A 2017;114:E11323-E11332The mechanism of thyroid hormone (TH) action is classically attributed to thyroid hormone receptor (THR) binding to thyroid hormone responsive elements (TRE) in promotors of target genes, directly controlling gene expression in target tissues. Thus, THRs alpha (TRa) and beta (TRb) function as TH dependent transcription ...

0 shares

ey0021.14-7 | Epi-/Genetics | ESPEYB21

14.7. Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs

Tomar A. , Gomez-Velazquez M. , Gerlini R. , Comas-Armangue G. , Makharadze L. , Kolbe T. , Boersma A. , Dahlhoff M. , Burgstaller J.P. , Lassi M. , Darr J. , Toppari J. , Virtanen H. , Kuhnapfel A. , Scholz M. , Landgraf K. , Kiess W. , Vogel M. , Gailus-Durner V. , Fuchs H. , Marschall S. , de Angelis M. Hrabě , Kotaja N. , Korner A. , Teperino R.

Brief Summary:This study in mice and humans shows how paternal overweight at conception affects the metabolism of their offspring. Sperm-borne mt-sncRNAs (mitochondrial encoded or derived small non-coding RNAs) are altered by a 2-week high fat diet (HFD) challenge in mice, likely through specific upregulation of mt-tsRNAs (mitochondrial transfer RNAs) caused by mitochondrial dysfunction. In humans, mt-tsRNAs in spermatozoa correlate with body mass index. Genetically engineered...

0 shares

ESPE Yearbook of Paediatric Endocrinology

3.4 Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

14.7. Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs

BiosciAbstracts