ISSN 1662-4009 (online)

ey0021.3-2 | Hypothalamus-Pituitary-Axis Regulation | ESPEYB21

3.2. Regulation of thyroid hormone levels by hypothalamic thyrotropin-releasing hormone neurons

Costa-E-Sousa Ricardo H , Rorato Rodrigo , Hollenberg Anthony N , Vella Kristen R

Brief Summary: This study examined the regulation of thyroid hormone (TH) levels by thyrotropin-releasing hormone (TRH) neurons located in the paraventricular nucleus (PVN) of the hypothalamus in fed and fasted mice. It focused on the role of agouti-related peptide (AgRP)/neuropeptide Y (NPY) neurons in the arcuate nucleus.Using chemogenetic activation in mice, the authors demonstrated that TRH neurons play a direct role in regulating the hypothalamic-pi...