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10.9. Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies

I Starskaia , M Valta , S Pietila , T Suomi , S Pahkuri , UU Kalim , al. et

Brief Summary: Longitudinally collected samples from the Type 1 Diabetes Prediction and Prevention (DIPP) study were used to assess potential differences in immune responses in children at genetic risk of type 1 diabetes (T1D) who later progressed to clinical disease, stratified by autoantibody appearance (IAA-first, GADA-first, ≥2 autoantibodies (AAb)-first groups). Differences in the composition of peripheral blood monoclonal cells (PBMC) were found between the IAA-fir...

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ey0015.14-1 | Why do women have more autoimmune disease than men? | ESPEYB15

14.1 Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

I Mohammad , I Starskaia , T Nagy , J Guo , E Yatkin , K Väänänen , WT Watford , Z Chen

To read the full abstract: Sci. Signal. 2018;11:eaap9415Women are more frequently affected by autoimmune disorders than men. A role for estrogen was suggested by the observation that the development of inflammatory bowel disease was associated with oral contraceptive use. Women also respond to infection and vaccination with higher antibody production and a T helper 2 (TH2) cell&#8211...

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ESPE Yearbook of Paediatric Endocrinology

10.9. Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies

14.1 Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

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