Abstract Search

8.3. Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex

M Mathieu , C Drelon , S Rodriguez , H Tabbal , A Septier , C Damon-Soubeyrand , T Dumontet , A Berthon , I Sahut-Barnola , C Djari , M Batisse-Lignier , JC Pointud , D Richard , G Kerdivel , MA Calmejane , V Boeva , I Tauveron , AM Lefrancois-Martinez , A Martinez , P Val

To read the full abstract: Proc Natl Acad Sci USA. 2018; 115(52): E12265E12274.The adrenal cortex plays a central role in regulating body homeostasis through the production of glucocorticoids and mineralocorticoids that control many important physiologic functions, such as metabolism, inflammation and arterial blood pressure. The production of these hormones, known as steroid...

0 shares

ey0020.6-1 | Mechanism of the Year | ESPEYB20

6.1. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice

D Dufour , T Dumontet , I Sahut-Barnola , A Carusi , M Onzon , E Pussard , JJ Wilmouth , J Olabe , C Lucas , A Levasseur , C Damon-Soubeyrand , JC Pointud , F Roucher-Boulez , I Tauveron , G Bossis , ET Yeh , DT Breault , P Val , AM Lefrancois-Martinez , A Martinez

Brief summary: This study investigates the role of SUMOylation in adrenal development and functionThe murine adrenal cortex is a constantly self-renewed endocrine organ composed of concentric zones, including the outermost zona glomerulosa (zG) producing mineralocorticoids and the innermost zona fasciculata (zF) producing glucocorticoids. According to the centripetal migration model occurring during postnatal development, progenitor cell populations loca...

0 shares

ESPE Yearbook of Paediatric Endocrinology

8.3. Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex

6.1. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice

BiosciAbstracts