ISSN 1662-4009 (online)

ey0018.11-14 | New insight into preconceptional and prenatal programming | ESPEYB18

11.14. Lifestyle intervention in pregnant women with obesity impacts cord blood DNA methylation, which associates with body composition in the offspring

J Jonsson , KM Renault , S Garcia-Calzon , A Perfilyev , AC Estampador , K Norgaard , M Vendelbo Lind , A Vaag , L Hjort , KF Michaelsen , E Malchau Carlsen , PW Franks , C Ling

Diabetes 2021 Apr;70(4):854–866. https://pubmed.ncbi.nlm.nih.gov/33431374/These authors performed a randomized trial of obese pregnant women (n=425) to investigate the effects of a pregnancy lifestyle intervention on epigenetic variations in umbilical cord blood, on neonatal body composition (DXA) and on offspring BMI in later life (up to 3 years). Offspring of mothers who re...