ey0021.4-10 | New Mechanisms | ESPEYB21
T Apaydin
, S Zonis
, C Zhou
, CW Valencia
, R Barrett
, GJ Strous
, JA Mol
, V Chesnokova
, S Melmed
Brief Summary: This study assessed the effect of growth hormone (GH) on WIP1 (wild-type p53-inducible phosphatase 1), a key mediator of the DNA damage response (DDR). GH suppressed DDR by inducing WIP1, which dephosphorylates and inactivates ATM (ataxia-telangiectasia mutated) kinase and its downstream effectors (such as CHK2, p53 and H2AX), leading to the accumulation of unrepaired DNA, which can potentially contribute to tumorigenesis.This elegant stud...