ESPE Yearbook of Paediatric Endocrinology

Brief summary: This study aimed to decipher the pathophysiology of the lower prevalence of diabetic retinopathy observed among youth with T2D who also have severe obesity. None of the several biomarkers assessed was found to be associated with the obesity paradox. The biomarkers included: inflammatory factors, acute phase reactants or cytokines (VEGF, hsCRP, ICAM-1, VCAM-1, homocysteine, adiponectin, E-selectin, MCP-1, TNF-α, IL-6, fibrinogen, and ApoB).<p class="abst...

Brief summary: This analysis of data from the TODAY study examined the impact of parental diabetes on outcomes in young individuals with T2D during over 12 years of follow-up. This novel observation demonstrates that parental diabetes affects not only earlier T2D onset, but also more rapid long-term progression and more complications.Comment: This study showed that T2D diagnosis in either parent was associated with younger age at T2D diagnosis in their c...

Brief Summary: This longitudinal observational study combined data from the SEARCH (T1D: N=564; T2D: N=149) and TODAY studies (T2D: N=495). Complications were higher in those with childhood onset T2D compared to T1D, with T2D showing 2.5 to 4 times higher rates of microvascular, macrovascular events despite similar diabetes duration. Risk factors for complications differed between T2D and T1D, with mean arterial pressure being a common predictor for both.<p class="abstext"...

Brief Summary: This observational study showed that pregnancy increases the risk of hyperfiltration in women with youth-onset T2D, but not other micro or macrovascular complications.Comment: This study examined whether pregnancy exacerbates health outcomes in young women with T2D, particularly by testing for changes in the occurrence of microvascular and macrovascular complications. Previous findings showed that women in their fourth decade experience a ...

Brief summary: A significant increase in the incidence T2D occurred in the USA during the COVID-19 pandemic, particularly among children with obesity and males.Comment: This is the first multicenter report on the incidence of T2D during the first year of the COVID-19 pandemic in the USA. The average number of new diagnoses per year in the two pre-pandemic years was 825, compared with 1463 during the first pandemic year. This increase of 77% is significan...