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ey0017.11-6 | Body Weight and Appetite/Energy Regulation | ESPEYB17

11.6. Leptin’s hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents

RJ Perry , JM Resch , AM Douglass , JC Madara , A Rabin-Court , H Kucukdereli , C Wu , JD Song , BB Lowell , GI Shulman

To read the full abstract: Proc Natl Acad Sci U S A 2019;116(27):1367013679. doi: https://pubmed.ncbi.nlm.nih.gov/31213533/In this paper, Perry et al. studied several animal models to disentangle the mechanism by which leptin suppresses hunger. In rats, the hyperphagia induced by a 48 h fast, or a hypoglycemic hyperinsulinemic clamp, or uncontrolled diabetes, was completely s...

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ey0020.9-5 | Advances in Understanding Central Weight Regulation and Behaviour | ESPEYB20

9.5. A synaptic amplifier of hunger for regaining body weight in the hypothalamus

K Grzelka , H Wilhelms , S Dodt , ML Dreisow , JC Madara , SJ Walker , C Wu , D Wang , BB Lowell , H Fenselau

Brief summary: Grzelka et al. identified a hypothalamic circuit that regulates regain of body weight after weight loss.Body weight is one of the most regulated variables of our body, which is most likely due to the evolutionary history of times when access to food was scarce and volatile. Weight loss triggers a strong counterregulatory response. It increases the hunger drive and greatly increases the reward value of food, making it more difficul...

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ey0016.7-1 | Basic Science | ESPEYB16

7.1. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

RA Ross , S Leon , JC Madara , D Schafer , C Fergani , CA Maguire , AM Verstegen , E Brengle , D Kong , AE Herbison , UB Kaiser , BB Lowell , VM Navarro

To read the full abstract: Elife. 2018 Jun 15;7. pii: e35960.Using transgenic mice, this team discover a new role for Pituitary adenylate cyclase activating polypeptide (PACAP) in female puberty and reproduction. This neuropeptide relays nutritional state information in the hypothalamus to regulate gonadotropin-releasing hormone release.Metabolic cues play...

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ESPE Yearbook of Paediatric Endocrinology

11.6. Leptin’s hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents

9.5. A synaptic amplifier of hunger for regaining body weight in the hypothalamus

7.1. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

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