ey0021.10-13 | New Biomarkers | ESPEYB21
JL Huang
, MS Pourhosseinzadeh
, S Lee
, N Kramer
, JV Guillen
, NH Cinque
, al. et
Brief Summary: This experimental study quantified the physiological contribution of pancreatic δ-cells to the glycemic set point. It used 3 orthogonal mouse models to remove somatostatin (SST) signalling within the pancreas or transplanted islets. Ablation of δ-cells or SST decreased the glycemic set point, and the glucose threshold for insulin response from β-cells, leading to increased insulin secretion to the same glucose challenge.The ...