ISSN 1662-4009 (online)

ey0021.10-13 | New Biomarkers | ESPEYB21

10.13. Paracrine signalling by pancreatic delta cells determines the glycaemic set point in mice

JL Huang , MS Pourhosseinzadeh , S Lee , N Kramer , JV Guillen , NH Cinque , al. et

Brief Summary: This experimental study quantified the physiological contribution of pancreatic δ-cells to the glycemic set point. It used 3 orthogonal mouse models to remove somatostatin (SST) signalling within the pancreas or transplanted islets. Ablation of δ-cells or SST decreased the glycemic set point, and the glucose threshold for insulin response from β-cells, leading to increased insulin secretion to the same glucose challenge.The ...