ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Endocrinology vol. 161,2 (2020): bqz041. doi: https://academic.oup.com/endo/article/161/2/bqz041/5698115This mouse study demonstrates the influence of maternal nutrition during lactation on offspring gut microbiota and its consequences on metabolism and puberty timing. Childhood obesity is a risk factor for the deve...

Brief Summary: IGF1R signaling in cells expressing Kiss1 gene affects energy balance, food intake, and physical activity in a sex-specific manner. Female IGF1RKiss1 mice showed lower body weight and food intake plus higher energy expenditure and physical activity. This phenotype was associated with higher proopiomelanocortin (POMC) expression. The additional deletion of insulin receptor (IR) in Kiss1-expressing cells reversed the lean phenotype seen in female IGF1R<...

Brief Summary: This review summarizes the role of macronutrients and hormones which regulate energy balance and sexual maturation by conveying energy availability information to the GnRH system.30 years ago, Kennedy and Mitra were the first to use translational studies to show that nutrition is a key factor regulating puberty timing1. Their seminal protocol modified the size of rat litters to affect weight increase and showed that nutritional ...