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ey0019.5-10 | Translational highlights | ESPEYB19

5.10. INZ-701 prevents ectopic tissue calcification and restores bone architecture and growth in ENPP1-deficient mice

Z Cheng , K O'Brien , J Howe , C Sullivan , D Schrier , A Lynch , S Jungles , Y Sabbagh , D Thompson

J Bone Miner Res. 2021 Aug;36(8):1594-1604.Abstract: https://pubmed-ncbi-nlm-nih-gov/33900645/In Brief: Enzyme replacement therapy with human ENPP1-Fc protein in Enpp1asj/asj mice, a murine model of ENPP1 deficiency, restored circulating levels of PPi, prevented clinical manifestations and decreased mortality.Commentary: ENPP1 deficiency causes gen...

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ey0019.8-1 | Mechanism of the year: neuropeptide substance P regulates aldosterone secretion | ESPEYB19

8.1. The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys

K Cheng , Y Seita , T Moriwaki , K Noshiro , Y Sakata , YS Hwang , T Torigoe , M Saitou , H Tsuchiya , C Iwatani , M Hosaka , T Ohkouchi , H Watari , T Umazume , K Sasaki

Sci Adv. 2022; 8(16): eabn8485. PMID: 35442744https://pubmed.ncbi.nlm.nih.gov/35442744/Brief Summary: This histologic and transcriptomic study of human and primate adrenal tissue samples provides a molecular framework to understand the fetal development of the adrenal gland.The adrenal cortex is the major source of steroid hormones that drive a plethora of critical ph...

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ESPE Yearbook of Paediatric Endocrinology

5.10. INZ-701 prevents ectopic tissue calcification and restores bone architecture and growth in ENPP1-deficient mice

8.1. The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys

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