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ey0020.4-2 | Sexuality, Fertility and Fertility Optimization in DSD | ESPEYB20

4.2. Generation of functional oocytes from male mice in vitro

K Murakami , N Hamazaki , N Hamada , G Nagamatsu , I Okamoto , H Ohta , Y Nosaka , Y Ishikura , TS Kitajima , Y Semba , Y Kunisaki , F Arai , K Akashi , M Saitou , K Kato , K Hayashi

Brief summary: This in vitro study reports that fully potent oocytes were generated from pluripotent stem cells of the tail of a sexually mature male mouse. These oocytes were able to give rise to offspring after fertilization.A particular challenge in the care of DSD patients in adulthood is the optimization of fertility potential. Fertility outcome is significantly reduced in all types of DSD depending on the underlying etiology as well as the...

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ey0021.9-5 | Fertility Issues | ESPEYB21

9.5. Fertility potential and gonadal function in survivors of reduced-intensity hematopoietic stem cell transplantation

SJ Rotz , BK Hamilton , W Wei , I Ahmed , SA Winston , S Ballard , RJ Bernard , P Carpenter , N Farhadfar , C Ferraro , BD Friend , NJ Gloude , RJ Hayashi , K Hoyle , K Jenssen , J Koo , CJ Lee , L Mariano , R Nawabit , A Ngwube , N Lalefar , R Phelan , L Perkins , A Rao , A Rayes , T Sandheinrich , L Stafford , K Tomlinson , S Whiteside , C Wiedl , K Myers

Brief Summary: This multicenter, international, retrospective study evaluated fertility potential and gonadal function in 326 adolescent and young adult cancer survivors. Risk factors for impairment included hematopoietic stem cell transplantation (HCT) conditioning regimen (myeloablative conditioning, MAC vs reduced-intensity conditioning, RIC).The prevalence of gonadal hormone failure in females was 55.3% (defined as FSH >30 mIU/mL with an estradio...

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ESPE Yearbook of Paediatric Endocrinology

4.2. Generation of functional oocytes from male mice in vitro

9.5. Fertility potential and gonadal function in survivors of reduced-intensity hematopoietic stem cell transplantation

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