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8.3 Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

K Kalafatakis , GM Russell , CJ Harmer , MR Munafo , N Marchant , A Wilson , JC Brooks , C Durant , J Thakrar , P Murphy , NJ Thai , SL Lightman

To read the full abstract: Proc Natl Acad Sci U S A. 2018; 115(17): E4091-E4100The hypothalamic-pituitary-adrenal axis is a critical neurohormonal network that regulates homeostasis and coordinates the stress response. Glucocorticoids (GCs) are critical for life and are key regulators of cognitive, metabolic and immunologic homeostasis (4). Clinical studies in healthy human subjects, usi...

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ey0021.8-12 | Clinical Trials – New Treatments | ESPEYB21

8.12. Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: the PULSES trial

G Russell , K Kalafatakis , C Durant , N Marchant , J Thakrar , R Thirard , J King , J Bowles , T Upton , NJ Thai , JCW Brooks , A Wilson , K Phillips , S Ferguson , M Grabski , CA Rogers , T Lampros , S Wilson , C Harmer , M Munafo , SL Lightman

Brief Summary: This 6-week randomized, crossover, double blind, placebo-controlled feasibility trial assessed the effect of subcutaneous pump hydrocortisone on the quality of life, mood, functional neuroimaging, behavioral/cognitive responses, sleep and metabolism in adults with primary adrenal insufficiency (PAI) compared to standard therapy.Comment: Adrenal glucocorticoid secretion is characterized by a complex diurnal variation, formed by changes in p...

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ESPE Yearbook of Paediatric Endocrinology

8.3 Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

8.12. Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: the PULSES trial

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