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ey0015.15-12 | Obesity must be studied separately in men and women | ESPEYB15

15.12 TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

C Wang , Y He , P Xu , Y Yang , K Saito , Y Xia , X Yan , A Hinton Jr , C Yan , H Ding

To read the full abstract: Nature Communications 2018;9:1544Obesity prevalence is generally higher in women than in men, and there is also a sex difference in body fat distribution. Sex differences in obesity can be explained in part by the influence of gonadal steroids on body composition and appetite; however, behavioural, and socio-cultural factors may also play a role. Here is th...

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ey0016.11-3 | New Insights into Body Weight Regulation | ESPEYB16

11.3. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

Y Yang , AA van der Klaauw , L Zhu , TM Cacciottolo , Y He , LKJ Stadler , C Wang , P Xu , K Saito , A Jr. Hinton , X Yan , JM Keogh , E Henning , MC Banton , AE Hendricks , EG Bochukova , V Mistry , KL Lawler , L Liao , J Xu , S O'Rahilly , Q Tong , UK10K Consortium , I Barroso , BW O'Malley , IS Farooqi , Y Xu

To read the full abstract: Nat Comm 2019; 10(1): 1718Steroid receptor coactivator (SRC)-1 mediates nuclear hormone receptors and transcription factor-dependent transcription (1), and interacts with STAT3 (2) an important mediator of leptin-induced POMC expression and hence satiety (3). Src-1 knockout mice are obese (4), however, the underlying mechanism is unclear. In a...

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ESPE Yearbook of Paediatric Endocrinology

15.12 TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

11.3. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

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