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ey0015.15-14 | Memories that persist into adulthood | ESPEYB15

15.14 Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

X Yuan , K Tsujimoto , K Hashimoto , K Kawahori , N Hanzawa , M Hamaguchi , T Seki , M Nawa , T Ehara , Y Kitamura

To read the full abstract: Nature Communications 2018;9:636We know that good nutrition early in life has profound and long-lasting effects on body weight in later life. Malnutrition during pregnancy or infant formula feeding may be stored on the offspring genome as epigenetic memory and persist into adulthood, thereby influencing the susceptibility to metabolic diseases, such as obes...

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ey0015.15-15 | How dangerous is Bisphenol A really? | ESPEYB15

15.15 FDA Statement from Foods and Veterinary Medicine, on National Toxicology Program draft report on Bisphenol A

X Yuan , K Tsujimoto , K Hashimoto , K Kawahori , N Hanzawa , M Hamaguchi , T Seki , M Nawa , T Ehara , Y Kitamura

To read the full report: https://www.fda.gov/NewsEventsThe report, issued by the U.S. National Toxicological Program (NTP), presents the initial results of a multimillion dollar study conducted for more than 5 years by scientists at FDA’s National Center for Toxicological Research. It looked at the effects of different doses of BPA evaluating chronic and e...

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ey0019.6-7 | Basic and Genetic Research of DSD | ESPEYB19

6.7. MAP3K1 variant causes hyperactivation of Wnt4/[beta]-catenin/FOXL2 signaling contributing to 46,XY disorders/differences of sex development

H Chen , Q Chen , Y Zhu , K Yuan , H Li , B Zhang , Z Jia , H Zhou , M Fan , Y Qiu , Q Zhuang , Z Lei , M Li , W Huang , L Liang , Q Yan , C Wang

Front Genet. 2022 Mar 3;13:736988. PMID: 35309143, doi: 10.3389/fgene.2022.736988.Brief Summary: This molecular study highlights a novel mechanism of action of Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) in the development of testicular dysgenesis.MAP3K1 is one of the most common genes that has been identified to cause 46, XY DSD and variants are attribu...

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ESPE Yearbook of Paediatric Endocrinology

15.14 Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

15.15 FDA Statement from Foods and Veterinary Medicine, on National Toxicology Program draft report on Bisphenol A

6.7. MAP3K1 variant causes hyperactivation of Wnt4/[beta]-catenin/FOXL2 signaling contributing to 46,XY disorders/differences of sex development

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