ESPE Yearbook of Paediatric Endocrinology

Brief Summary: this longitudinal study found no statistical difference between boys and girls regarding the timing of increase in nocturnal luteinizing hormone concentrations.Puberty results from a gradual increase in GnRH secretion, that can be monitored by urinary gonadotropin measurements. Timing of normal puberty, initially described by Marshal and Tanner, is characterized by an important individual variability in humans1,2. The difference...

To read the full abstract: J Clin Endocrinol Metab. 2018 Jan 1;103(1):228-234[Comments on 7.5 and 7.6] Remarkably, the timing of puberty shows important differences between individuals1. Based on twin studies, differences in pubertal timing are considered to depend on genetic factors which account for up to 60-70% of the varianc...

Brief summary: This long-term longitudinal study of 437 Danish girls shows that AMH level measured in infancy is a useful tool to predict future ovarian activity.Anti-Müllerian hormone (AMH) is produced by granulosa cells in small ovarian follicles and thus reflects the ovarian reserve of resting primordial follicles (1). High AMH concentrations are observed in women with polycystic ovarian syndrome (PCOS) (2), while low age-specific AMH could be as...

J Clin Endocrinol Metab. 2022;107(7):1965-75. doi: 10.1210/clinem/dgac173.PubMed ID: 35323957Brief summary: This population-based birth cohort study related infancy serum testosterone concentrations at age 3 months to parameters of reproductive function at age 18 to 20 years in 259 males. Serum testosterone in infancy predicted adult total sperm counts, and other reproductive hormones and geni...

J Clin Endocrinol Metab. 2018 Aug 1;103(8):3028–3037.doi: 10.1210/jc.2018-00482. PubMed ID: 29917083Minipuberty is a poorly understood developmental event at 1–6 months of age, during which the hypothalamic-pituitary-gonadal axis is transiently activated.This study assessed serum reproductive hormone concentrations in 1840 healthy boys ...

Brief summary: The objective of this study was to examine whether IGF-I and IGF-binding protein-3 (IGFBP-3) levels track through childhood into adulthood and to estimate the cumulative lifetime exposure to IGF-I in healthy individuals and in individuals with a defined period of increased IGF-I levels because of GH therapy.Measurement of serum IGF-I is a cornerstone in rhGH treatment monitoring. Keeping serum IGF-I concentrations within the normal referen...

Brief Summary: this retrospective study describes clinical and biochemical parameters which, using the principal component analysis, help in the differential diagnosis between idiopathic central precocious puberty (ICPP) and premature thelarche (PT).Breast development in girls before 8 years of age may be related to progressive CPP but can sometimes simply be the consequence of premature thelarche without activation of the hypothalamic-pituitary-gonadal ...

To read the full abstract: Journal of clinical endocrinology and metabolism vol. 105,3 (2020):754–768. doi: https://academic.oup.com/jcem/article/105/3/754/5624050The authors used state-of-the-art liquid chromatography tandem mass spectrometry to establish sex-specific reference ranges for estrone (E1) and estradiol (E2) throughout life and evaluate sex-differences.</...

Brief summary: This prospective longitudinal study compared serum reproductive hormone levels and testicular volume around the onset of puberty between cryptorchid and healthy boys.Congenital cryptorchidism is the most common congenital anomaly among newborn boys, and still little is known about pubertal testicular function and serum reproductive hormone levels during puberty in this population.Pubertal follow-up with clinical exam...

Eur J Endocrinol. 2020 Jun;182(6):P1–P15. doi: 10.1530/EJE-19-0831. PMID: 32268295.This paper describes the concerted efforts of the EU COST Action DSDNet and the European network for rare endocrine diseases Endo-ERN. A total of 33 laboratories were involved and they describe state of the art assessments of the peptide hormones: follicle-stimulating hormone (FSH), luteinizing hormone (LH)...