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ey0019.1-4 | Basic Science and Stem Cells | ESPEYB19

1.4. Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

P Russell John , Lim Xinhong , Santambrogio Alice , Yianni Val , Kemkem Yasmine , Wang Bruce , Fish Matthew , Haston Scott , Grabek Anae¨lle , Hallang Shirleen , J Lodge Emily , L Patist Amanda , Schedl Andreas , Mollard Patrice , Nusse Roel , Andoniadou Cynthia L

Elife. 2021 Jan. 10:e59142. doi: https://doi.org/10.7554/eLife.59142.Brief Summary: The authors studied genetic mice models to show that pituitary stem cells can secrete WNT ligands to their committed progeny and promote their expansion.The anterior pituitary contains a population of Sox2 expressing stem cells (Sox2+ PSCs), which self-renew and give rise to lineage...

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ey0021.3-3 | Hypothalamus-Pituitary-Axis Regulation | ESPEYB21

3.3. TSH pulses finely tune thyroid hormone release and TSH receptor transduction

Guillou Anne , Kemkem Yasmine , Lafont Chrystel , Fontanaud Pierre , Calebiro Davide , Campos Pauline , Bonnefont Xavier , Fiordelisio-Coll Tatiana , Wang Ying , Brule Emilie , Bernard Daniel J , Tissier Paul Le , Steyn Frederik , Mollard Patrice

Brief Summary: This study examined the pulsatile secretion of TSH and its regulatory role in thyroid hormone (TH) synthesis in mice. Using a novel ultra-sensitive ELISA for mouse TSH, it shows that TSH pulsatility plays a critical role in regulating thyroid function.In addition to mapping the normal TSH secretion pattern in healthy mice, and the secretion pattern in a mouse model of disease (mouse made hypothyroid by an iodine-deficient diet enriched wit...

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ESPE Yearbook of Paediatric Endocrinology

1.4. Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

3.3. TSH pulses finely tune thyroid hormone release and TSH receptor transduction

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