ESPE Yearbook of Paediatric Endocrinology

Brief summary: This 12-months randomized, controlled, phase 3 study compared the efficacy and safety of once-weekly Somatrogon 0.66 mg/kg/week with once-daily somatropin in prepubertal children with GHD. The efficacy of once-weekly Somatrogon was noninferior to once-daily somatropin, with similar safety and tolerability profiles.Somatrogon (MOD-4023) is a long-acting rhGH recently approved by the European Medicines Agency for the treatment of children wi...

Brief Summary: This prospective cohort study of 146 mother-neonate pairs determined fetal-maternal exposure to EDCs from October 2021 – October 2022 and examined their associations with fetal growth parameters. Fetal exposure to bisphenol-A (BPA) showed a linear association with asymmetric fetal growth patterns.Their definition of fetal growth restriction (FGR) when assessed by transabdominal ultrasonography at 38.3 weeks gestational age was a fetal...

Brief Summary: The authors propose a simplified definition of pediatric metabolic syndrome (MetS) for children aged 6-17 years. This uses static cut-offs, enabling easier and quicker assessment in clinical practice, and allowing comparison of MetS prevalence across different pediatric populations.Comment: There is no consensus on the definition of pediatric metabolic syndrome (MetS). Existing pediatric MetS definitions involve age-, sex- or height-specif...