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15.16. The effects of 20-kDa human placental GH in male and female GH-deficient mice: an improved human GH?

List Edward O , Berryman Darlene E , Basu Reetobrata , Buchman Mathew , Funk Kevin , Kulkarni Prateek , Duran-Ortiz Silvana , Qian Yanrong , Jensen Elizabeth A , Young Jonathan A , Yildirim Gozde , Yakar Shoshana , Kopchick John J

Endocrinology 2020 Aug 1;161(8):bqaa097.https://bit.ly/3zqg6c5This study, in a GH-deficient mouse model, shows that a 20-kDa variant of placental GH (20k-GH-V) retains the growth-promoting effects of normal pituitary-derived GH (GH-N), but with the advantages of having no diabetogenic or prolactin receptor (PRLR)-mediated tumour-promoting effects.One of the first described actions of GH...

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ey0016.15-10 | (1) | ESPEYB16

15.10. Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons

Furigo Isadora C , Teixeira Pryscila DS , de Souza Gabriel O , Couto Gisele CL , Romero Guadalupe Garcia , Perello Mario , Frazao Renata , Elias Lucila L , Metzger Martin , List Edward O , Kopchick John J , Donato J

To read the full abstract: Nature Communications, 2019; 10 (1); 662This paper highlights the brain as a key target for growth hormone (GH) signaling affecting mostly energy conservation. To identify GH response neurons, C57BL/6 mice received intraperitoneal injection of saline or GH and their brains were processed to detect the phosphorylation of pSTAT5 as a marker of GH receptor a...

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ESPE Yearbook of Paediatric Endocrinology

15.16. The effects of 20-kDa human placental GH in male and female GH-deficient mice: an improved human GH?

15.10. Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons

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