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15.4. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

A Wesolowska-Andersen , CA Brorsson , R Bizzotto , A Mari , A Tura , R Koivula , A Mahajan , A Vinuela , JF Tajes , S Sharma , M Haid , C Prehn , A Artati , MG Hong , PB Musholt , A Kurbasic , F De Masi , K Tsirigos , HK Pedersen , V Gudmundsdottir , CE Thomas , K Banasik , C Jennison , A Jones , G Kennedy , J Bell , L Thomas , G Frost , H Thomsen , K Allin , TH Hansen , H Vestergaard , T Hansen , F Rutters , P Elders , L t'Hart , A Bonnefond , M Canouil , S Brage , T Kokkola , A Heggie , D McEvoy , A Hattersley , T McDonald , H Teare , M Ridderstrale , M Walker , I Forgie , GN Giordano , P Froguel , I Pavo , H Ruetten , O Pedersen , E Dermitzakis , PW Franks , JM Schwenk , J Adamski , E Pearson , MI McCarthy , S Brunak , Consortium ID

Cell Rep Med. 2022;3(1):100477. doi: 10.1016/j.xcrm.2021.100477. PubMed ID: 35106505Brief summary: To explore clinical heterogeneity, this study analyzed baseline visit data on 726 adults with newly diagnosed Type 2 diabetes (T2D) adults and identified in 4 distinct profiles (clusters of phenotypes), which predicted differences in subsequent disease progression and anti-diabetic treatments...

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ey0021.9-16 | Bone Health and Chronic Diseases | ESPEYB21

9.16. Vertebral body reshaping after fractures: an important index of recovery in glucocorticoid-treated children

J Ma , K Siminoski , JL Jaremko , K Koujok , MA Matzinger , N Shenouda , N Wilson , M Cheng , N Alos , S Atkinson , EA Cummings , J Ho , C Rodd , AM Sbrocchi , R Stein , R Barr , E Cairney , DB Dix , CV Fernandez , R Grant , J Halton , S Israels , C Laverdiere , VA Lewis , DA Cabral , A Huber , K Houghton , R Jurencak , B Lang , M Larche , CMA LeBlanc , P Miettunen , J Roth , R Scuccimarri , L Bell , T Blydt-Hansen , G Filler , J Feber , V Phan , K Smit , F Rauch , LM Ward

Brief Summary: This prospective natural history study examined the timing and positive indicators for reshaping of vertebral fractures (VF) in glucocorticoid (GC)-treated patients with chronic diseases. Complete VF reshaping occurred in 82.3% of patients, with similar frequencies in all diagnosis groups (leukemia, rheumatic disorders and nephrotic syndrome) in a median time of 1.3 years. Likelihood of VF reshaping was positively related to higher lumbar spine bone mineral dens...

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ESPE Yearbook of Paediatric Endocrinology

15.4. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

9.16. Vertebral body reshaping after fractures: an important index of recovery in glucocorticoid-treated children

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