ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This paper reviewed the toxicity of radiation therapy (RT) on ovarian, uterine and vaginal tissue in childhood cancer survivors (CCSs), using data published from 1970 to 2017. Overall, 11 studies reported data on ovarian damage, 8 on uterine volume related to treatment, and 3 on vaginal effects. Most studies did not report accurate dosimetric data and dose-volume relationships, and the confounder role of chemotherapy was not considered. In general, published dat...

Brief Summary: This review analysed 15 original studies reporting the effects of radiation therapy (RT) on thyroid gland in childhood cancer survivors (CCS). A relationship between RT dose to the thyroid gland and risk of hypothyroidism could be extrapolated from 8/15 studies. Risk of compensated hypothyroidism increased with RT dose to the thyroid: it was 12%, 25% and 44% at 10, 20 and 30 Gy, respectively. Similarly, the risk of overt hypothyroidism was 4%, 7% and 13% at 10, ...

Brief summary: In this extensive and updated review, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) report expert consensus-based guidelines that harmonize recommendations for surveillance of endocrine disorders in childhood cancer survivors.This interdisciplinary panel of 42 international experts formulated new surveillance recommendations for hypothalamic–pituitary (HP) dysfunction. Existing IGHG surveillan...