ey0020.12-13 | Food for Thought | ESPEYB20
M Witkowski
, I Nemet
, H Alamri
, J Wilcox
, N Gupta
, N Nimer
, A Haghikia
, XS Li
, Y Wu
, PP Saha
, I Demuth
, M Konig
, E Steinhagen-Thiessen
, T Cajka
, O Fiehn
, U Landmesser
, WHW Tang
, SL Hazen
Brief summary: This observational study in three different cohorts found an increased risk for atherothrombotic disease associated with the commonly used sugar substitute erythritol. Untargeted metabolomics (in cohort 1, n=1157) and targeted metabolomics (in cohorts 2 and 3, n=2149 USA and n=833 Europe, respectively) investigations revealed an increased risk for major adverse cardiovascular events (MACE) including death, myocardial infarction and str...