ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0021.14-14 | Risk and Outcome | ESPEYB21

14.14. Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids

Auger Jean-Philippe , Zimmermann Max , Faas Maria , Stifel Ulrich , Chambers David , Krishnacoumar Brenda , Taudte R. Verena , Grund Charlotte , Erdmann Gitta , Scholtysek Carina , Uderhardt Stefan , Brahim Oumaima Ben , Mate Monica Pascual , Stoll Cornelia , Bottcher Martin , Palumbo-Zerr Katrin , Mangan Matthew S.J. , Dzamukova Maria , Kieler Markus , Hofmann Melanie , Bluml Stephan , Schabbauer Gernot , Mougiakakos Dimitrios , Sonnewald Uwe , Hartmann Fabian , Simon David , Kleyer Arnd , Gruneboom Anika , Finotto Susetta , Latz Eicke , Hofmann Jorg , Schett Georg , Tuckermann Jan , Kronke Gerhard

Brief Summary:This study uncovers a novel mechanism for the anti-inflammatory effects of glucocorticoids (GCs) that involves reprogramming of mitochondrial metabolism in macrophages through enhanced production of the anti-inflammatory metabolite itaconate and consequent inhibition of the inflammatory response. GCs have very potent anti-inflammatory properties, but the mechanisms are incompletely understood. GCs also have severe side effects when used in high doses for long-ter...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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