ey0021.3-5 | Thyroid Function - Genetic Determinants and Associations with Health and (Thyroid) Disease | ESPEYB21
Sterenborg Rosalie B T M
, Steinbrenner Inga
, Li Yong
Brief Summary: This genome-wide association study (GWAS) meta-analysis of 271,040 European participants investigated the genetic determinants of thyroid function, including reference range serum TSH, FT4, free and total T3, proxies for metabolism (T3/FT4 ratio), as well as dichotomized high and low TSH levels. It identified 259 independent associations for TSH, 85 for FT4, and novel associations for thyroid hormone (TH) metabolism (T3/FT4 ratio). Genetic variants explained 14....