ESPE Yearbook of Paediatric Endocrinology

JAMA Netw Open. 2020;3(10):e2015665. 10.1001/jamanetworkopen.2020.15665.. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2771377In brief: This Danish population-based 20-year cohort study provides strong epidemiological data supporting substantial increases in central precocious pub...

To read the full abstract: JAMA Pediatr. 2020;174(4):e195881. doi: 10.1001/jamapediatrics.2019.5881• The authors evaluated the change in pubertal onset in healthy girls around the world based on age at thelarche.• Overall, the age at thelarche decreased 0.24 years per decade from 1977 to 2013.• This decrease seems to reflect a worldwide trend....

To read the full abstract: Diabetes Care. 2019;42:1297–1304In normal populations, high BMI is associated with higher mortality and morbidity, in particular from cardiovascular disease (CVD). In contrast, in type 1 diabetes (T1D), low body weight has been associated with increased mortality risks. This study investigated the importance of weight and weight gain/loss in patients with ...

Diabetes 2021 Apr;70(4):854–866. https://pubmed.ncbi.nlm.nih.gov/33431374/These authors performed a randomized trial of obese pregnant women (n=425) to investigate the effects of a pregnancy lifestyle intervention on epigenetic variations in umbilical cord blood, on neonatal body composition (DXA) and on offspring BMI in later life (up to 3 years). Offspring of mothers who re...

Translational psychiatry 2022;12(1):59. doi: 10.1038/s41398-022-01817-0Brief Summary: This population genetics study explored pairwise genome-wide genetic correlations between neuropsychiatric disorders with insulin-related somatic diseases and traits. There were likely protective effects of obsessive-compulsive disorder and anorexia nervosa on the risks of having MetS, obesity and T2DM; i...