ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This register-based cohort study compared the familial aggregation and heritability of childhood-onset (≤18 years) vs. adult-onset (19-30 years) type 1 diabetes (T1D), using data collected from over 2.9 million individuals born in Sweden between 1982-2010, and from their relatives. Adult-onset T1D showed weaker familial aggregation and lower heritability than childhood-onset T1D.Although T1D is considered a typical childhood...

Nat Commun. 2020;11:4807. doi: 10.1038/s41467-020-18497-3.This interesting paper illustrates the potential of machine learning to improve the sensitivity and specificity of routine techniques in clinical practice if large cohorts for training and validation of models are used. Yu et al. present a transfer learning model (machine learning approach to solve research problems by r...

In Brief: The authors present ‘RETFound’, a self-supervised learning approach that has so far analysed 1.6 million retinal images to enable disease detection. RETFound shows good accuracy for diagnosis and prognosis of sight-threatening eye diseases. It also contributes to incident prediction of complex systemic disorders such as heart failure and myocardial infarction.The well-known saying ‘the eyes are the window to the soul’ means ...