ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0019.6-3 | Co-morbidities associated with DSD | ESPEYB19

6.3. Vascular dysfunction and increased cardiovascular risk in hypospadias

AK Lucas-Herald , AC Montezano , R Alves-Lopes , L Haddow , M Alimussina , S O'Toole , M Flett , B Lee , SB Amjad , M Steven , K Brooksbank , L McCallum , C Delles , S Padmanabhan , SF Ahmed , RM Touyz

Eur Heart J. 2022 Mar 17:ehac112. PMID: 35296881, doi: 10.1093/eurheartj/ehac112.Brief Summary: This translational study explored the molecular and cellular mechanisms whereby testosterone impacts vascular function. The findings suggest that hypospadias is associated with vascular dysfunction and represents a risk factor for hypertension and cardiovascular disease in adulthood due to impair...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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