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ey0017.5-10 | Novel Receptor Signaling Mechanisms | ESPEYB17

5.10. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodelling

S Nishimori , MJ O’Meara , CD Castro , H Noda , M Cetinbas , J da Silva Martins , U Ayturk , DJ Brooks , M Bruce , M Nagata , W Ono , CJ Janton , ML Bouxsein , M Foretz , R Berdeaux , RI Sadreyev , T Gardella , H Juppner , HM Kronenberg , MN Wein

To read the full abstract: J Clin Invest 2019;129:51875203.In brief: This report establishes inhibition of salt-inducible kinases as a central mechanism by which the parathyroid hormone 1 receptor (PTH1R) exerts its effects in both growth plate chondrocytes and osteoblasts/osteocytes during skeletal development, growth, and remodelling.Commentary</e...

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ey0016.14-15 | (1) | ESPEYB16

14.15. Recovery of trait heritability from whole genome sequence data

Wainschtein Pierrick , Jain Deepti P , Yengo Loic , Zheng Zhili , Anthropometry Working Group TOPMed , for Precision Medicine Consortium Trans-Omics , Cupples L Adrienne , Shadyab Aladdin H , McKnight Barbara , Shoemaker Benjamin M , Mitchell Braxton D , Psaty Bruce M , Kooperberg Charles , Roden Dan , Darbar Dawood , Arnett Donna K , Regan Elizabeth A , Boerwinkle Eric , Rotter Jerome I , Allison Matthew A , McDonald Merry-Lynn N , Chung Mina K , Smith Nicholas L , Ellinor Patrick T , Vasan Ramachandran S , Mathias Rasika A , Rich Stephen S , Heckbert Susan R , Redline Susan , Guo Xiuqing , Chen Y-D Ida , Liu Ching-Ti , Andrade Mariza de , Yanek Lisa R , Albert Christine M , Hernandez Ryan D , McGarvey Stephen T , North Kari E , Lange Leslie A , Weir Bruce S , Laurie Cathy C , Yang Jian , Visscher Peter M

bioRxiv March 25, 2019. doi: https://doi.org/10.1101/588020The Yearbook does not usually report on studies that are yet published only on preprint servers, i.e. author-deposited versions of papers that have not been accepted or even peer-reviewed. However, Nature also made an exception for this paper (1)!These authors analysed whole genome sequen...

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ESPE Yearbook of Paediatric Endocrinology

5.10. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodelling

14.15. Recovery of trait heritability from whole genome sequence data

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