ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This review describes progress of our understanding of insulin action in the brain, as well as the consequences of brain insulin resistance. Insulin resistance of the brain results in impaired modulation of peripheral metabolism, the maintenance of obesity and an unfavorable body fat distribution. Current evidence suggest that brain insulin resistance is a treatable condition, thereby improving systemic metabolism and brain functions including cognition.<p c...

To read the full abstract: Nat Commun. 2020;11(1):1841. Published 2020 Apr 15. doi: https://pubmed.ncbi.nlm.nih.gov/32296068/This study by Kullmann et al. investigated the impact of brain insulin resistance on medium and long-term changes in body weight and body fat in adults at high risk for T2DM, undergoing a 24-months lifestyle intervention program (n =28 at the 24-mont...