ISSN 1662-4009 (online)

ey0019.11-6 | New findings in adipose tissue biology | ESPEYB19

11.6. Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Q Li , CE Hagberg , HS Cascales , S Lang , MT Hyvonen , F Salehzadeh , P Chen , I Alexandersson , E Terezaki , MJ Harms , M Kutschke , N Arifen , N Kramer , M Aouadi , C Knibbe , J Boucher , A Thorell , KL Spalding

kirsty.spalding@ki.se Nat Med 2021; 27(11): 1941–1953 doi: 10.1038/s41591-021-01501-8Brief Summary: This study analysed adipocytes from obese and hyperinsulinemic adults. They demonstrate that obesity is associated with the induction of a cell cycle program in mature adipocytes, leading to so-called endoreplication, as a strategy to remain fu...

ey0016.10-3 | (1) | ESPEYB16

10.3. Psychosocial benefits of insulin pump therapy in children with diabetes type 1 and their families: The pumpkin multicenter randomized controlled trial

E Mueller-Godeffroy , R Vonthein , C Ludwig-Seibold , B Heidtmann , C Boettcher , M Kramer , N Hessler , D Hilgard , E Lilienthal , A Ziegler , VM Wagner , German Working Group for Pediatric Pump Therapy (agip) Wagner

To read the full abstract: Pediatr Diabetes. 2018;19:1471–1480It has been debated whether or not new technologies, in particular the combination of insulin pumps and continuous glucose testing, will improve patient satisfaction and quality of life rather than only metabolic control and risk of microvascular complications. Indeed, the use of continuous subcutaneous insulin infusion (...