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ey0021.8-1 | Mechanism of the Year | ESPEYB21

8.1. Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland

A Witt , I Mateska , A Palladini , A Sinha , M Wolk , A Harauma , N Bechmann , C Pamporaki , A Dahl , M Rothe , I Kopaliani , C Adolf , A Riester , B Wielockx , SR Bornstein , M Kroiss , M Peitzsch , T Moriguchi , M Fedorova , M Grzybek , T Chavakis , P Mirtschink , VI Alexaki

Brief Summary: This study demonstrates that FADS2 is a major regulator of steroidogenesis in the adrenal gland due to its key role in shaping the lipidomic landscape of adrenocortical cells.Comment: The corticosteroids aldosterone and cortisol are produced in the zona glomerulosa and zona fasciculata of the adrenal cortex, respectively (1, 2). Excess production of aldosterone in primary hyperaldosteronism results in resistant hypertension and cardiovascu...

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ey0021.8-15 | New Hope | ESPEYB21

8.15. Metastatic pheochromocytoma and paraganglioma: somatostatin receptor 2 expression, genetics, and therapeutic responses

A Fischer , S Kloos , U Maccio , J Friemel , H Remde , M Fassnacht , C Pamporaki , G Eisenhofer , HJLM Timmers , M Robledo , SMJ Fliedner , K Wang , J Maurer , A Reul , K Zitzmann , N Bechmann , G Žygienė , S Richter , C Hantel , D Vetter , K Lehmann , H Mohr , NS Pellegata , M Ullrich , J Pietzsch , CG Ziegler , SR Bornstein , M Kroiss , M Reincke , K Pacak , AB Grossman , F Beuschlein , S Nolting

Brief Summary: This study explored the relationship between Somatostatin Receptor 2 (SSTR2) immunoreactivity and succinate dehydrogenase complex iron sulfur subunit B (SDHB) immunoreactivity, mutational status, and clinical behavior of paragangliomas (PPGLs), and evaluated SSTR-based therapies in metastatic PPGLs. The findings highlight SSTR2 expression as a novel biomarker for metastatic behavior in PCC, PGL and SDHB/ SDHx mutations. They also suggest that SSTR-based therapie...

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ey0018.8-7 | Important for Clinical Practice | ESPEYB18

8.7. Targeted metabolomics as a tool in discriminating endocrine from primary hypertension

Z Erlic , P Reel , S Reel , L Amar , A Pecori , CK Larsen , M Tetti , C Pamporaki , C Prehn , J Adamski , A Prejbisz , F Ceccato , C Scaroni , M Kroiss , MC Dennedy , J Deinum , K Langton , P Mulatero , M Reincke , L Lenzini , AP Gimenez-Roqueplo , G Assie , A Blanchard , MC Zennaro , E Jefferson , F Beuschlein

J Clin Endocrinol Metab. 2021 Mar 25;106(4):11111128.https://pubmed.ncbi.nlm.nih.gov/33382876/In this multicentre patient cohort study, the authors investigated the use of targeted metabolomics to discriminate primary hypertension (PHT) from endocrine forms of hypertension (EHT). They identified 16 metabolites that help to discriminate between PHT and EHT.Arteri...

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ey0016.15-1 | (1) | ESPEYB16

15.1. A Copeptin-based approach in the diagnosis of diabetes insipidus

W Fenske , J Refardt , I Chifu , I Schnyder , B Winzeler , J Drummond , A Jr. Ribeiro-Oliveira , T Drescher , S Bilz , DR Vogt , U Malzahn , M Kroiss , E Christ , C Henzen , S Fischli , A Tonjes , B Mueller , J Schopohl , J Flitsch , G Brabant , M Fassnacht , M Christ-Crain

To read the full abstract: N Engl J Med 2018;379:428439In this multi-centre cohort of 156 patients with hypotonic polyuria, direct measurement of hypertonic saline-stimulated plasma copeptin had much greater diagnostic accuracy than a standard water-deprivation test, as judged by the final reference diagnosis, which was determined on the basis of medical history, test result...

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ESPE Yearbook of Paediatric Endocrinology

8.1. Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland

8.15. Metastatic pheochromocytoma and paraganglioma: somatostatin receptor 2 expression, genetics, and therapeutic responses

8.7. Targeted metabolomics as a tool in discriminating endocrine from primary hypertension

15.1. A Copeptin-based approach in the diagnosis of diabetes insipidus

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