ISSN 1662-4009 (online)

ey0020.4-5 | Novel Players in the Pathogenesis of DSD | ESPEYB20

4.5. CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice

N Okashita , R Maeda , M Tachibana

Brief summary: This in vivo study identifies a new gene, CDYL (Chromodomain Y-like protein) in the epigenetic control of sex determination in mice.Recent findings on mammalian sex development suggest that the fate decision of bipotential gonads depends not only on transcriptional activation of Y-linked testis-determining gene (SRY/Sry) but also on a delicate expression balance between the mutually antagonistic pro-testis and pro-ovarian genes. P...

ey0021.8-4 | Important for Clinical Practice | ESPEYB21

8.4. Incidence and risk factors for adrenal crisis in pediatric-onset adrenal insufficiency: a prospective study

M Hosokawa , Y Ichihashi , Y Sato , N Shibata , K Nagasaki , K Ikegawa , Y Hasegawa , T Hamajima , F Nagamatsu , S Suzuki , C Numakura , N Amano , G Sasaki , K Nagahara , S Soneda , D Ariyasu , M Maeda , H Kamasaki , K Aso , T Hasegawa , T Ishii

Brief Summary: This study examined the incidence and risk factors for adrenal crisis (AC) in patients with pediatric-onset adrenal insufficiency (AI). AC occurs in a substantial number of children with AI, particularly in younger children due to their high number of infections.Comment: Adrenal crisis (AC) is a life-threatening complication in patients with adrenal insufficiency (AI) (1-4). The clinical features of AC are often nonspecific, and it may be ...