ISSN 1662-4009 (online)

ey0018.6-16 | Longterm Effects of Hormonal Treatments in Gender Dysphoria | ESPEYB18

6.16. Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

A Weill , P Nguyen , M Labidi , B Cadier , T Passeri , L Duranteau , AL Bernat , I Yoldjian , S Fontanel , S Froelich , J Coste

BMJ. 2021 Feb 3;372:n37. doi: 10.1136/bmj.n37. PMID: 33536184This observational cohort study used data from the French administrative healthcare database during 2007–2015 to assess the risk of meningioma development related to treatment with cyproterone acetate. The cohort comprised 253,777 participants, of whom 54% had high exposure to cyproterone acetate, and 45% had low exposure.<p cla...

ey0021.15-6 | New Concerns | ESPEYB21

15.6. Consumption of 100% fruit juice and body weight in children and adults: a systematic review and meta-analysis

M Nguyen , SE Jarvis , L Chiavaroli , SB Mejia , A Zurbau , TA Khan , DK Tobias , WC Willett , FB Hu , AJ Hanley , CS Birken , JL Sievenpiper , VS. Malik

In Brief This systematic review collated evidence from prospective cohort studies (PCS) with at least 6 months follow-up and randomized clinical trials (RCTs) to assess the influence of 100% fruit juice on body weight in children and adults. 100% fruit juice intake was associated with higher BMI gain among children and with higher weight gain in adults.In children, 17 PCS (total 45,851 children) and no RCTs were identified. Each additional serving per da...

ey0020.13-1 | Section | ESPEYB20

13.1. Taurine deficiency as a driver of aging

P Singh , K Gollapalli , S Mangiola , D Schranner , MA Yusuf , M Chamoli , SL Shi , B Lopes Bastos , T Nair , A Riermeier , EM Vayndorf , JZ Wu , A Nilakhe , CQ Nguyen , M Muir , MG Kiflezghi , A Foulger , A Junker , J Devine , K Sharan , SJ Chinta , S Rajput , A Rane , P Baumert , M Schonfelder , F Iavarone , G di Lorenzo , S Kumari , A Gupta , R Sarkar , C Khyriem , AS Chawla , A Sharma , N Sarper , N Chattopadhyay , BK Biswal , C Settembre , P Nagarajan , KL Targoff , M Picard , S Gupta , V Velagapudi , AT Papenfuss , A Kaya , MG Ferreira , BK Kennedy , JK Andersen , GJ Lithgow , AM Ali , A Mukhopadhyay , A Palotie , G Kastenmuller , M Kaeberlein , H Wackerhage , B Pal , VK Yadav

In Brief: The authors describe a wide range of studies. Firstly, observational studies showed that circulating taurine concentrations decline with age in mice, monkeys, and humans – and in the latter, low taurine was associated with metabolic disease (abdominal fat, blood pressure, Type 2 diabetes). They then gave oral taurine to mice throughout their lives and showed that this increased lifespan by 10–12% and improved functional outcomes of almost all tissues studie...