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8.2. Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress

C Steenblock , MF Rubin de Celis , LF Delgadillo Silva , V Pawolski , A Brennand , M Werdermann , I Berger , A Santambrogio , M Peitzsch , CL Andoniadou , AV Schally , SR Bornstein

To read the full abstract: Proc Natl Acad Sci USA. 2018; 115(51): 1299713002.Humans are constantly challenged by multiple stressors, to which the bodys response and adaptation are essential. The adrenal gland plays a major role in the response to both physiological challenges and stress. Maintenance of the adrenal is partly accomplished by proliferation and differentiat...

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ey0021.8-1 | Mechanism of the Year | ESPEYB21

8.1. Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland

A Witt , I Mateska , A Palladini , A Sinha , M Wolk , A Harauma , N Bechmann , C Pamporaki , A Dahl , M Rothe , I Kopaliani , C Adolf , A Riester , B Wielockx , SR Bornstein , M Kroiss , M Peitzsch , T Moriguchi , M Fedorova , M Grzybek , T Chavakis , P Mirtschink , VI Alexaki

Brief Summary: This study demonstrates that FADS2 is a major regulator of steroidogenesis in the adrenal gland due to its key role in shaping the lipidomic landscape of adrenocortical cells.Comment: The corticosteroids aldosterone and cortisol are produced in the zona glomerulosa and zona fasciculata of the adrenal cortex, respectively (1, 2). Excess production of aldosterone in primary hyperaldosteronism results in resistant hypertension and cardiovascu...

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ESPE Yearbook of Paediatric Endocrinology

8.2. Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress

8.1. Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland

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