ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This study shows that obesity induces mitochondrial fragmentation and reduces oxidative capacity in white adipocytes through the activation of the small GTPase RalA. Targeted deletion of RalA in these cells prevents mitochondrial fragmentation, improves energy expenditure, and protects against obesity-induced metabolic dysfunctions, highlighting the critical role of RalA in obesity-related mitochondrial and metabolic abnormalities.Previous...

To read the full abstract: Trends Endocrinol Metab. 2018; 29(10):675–685This paper comprehensively reviews current knowledge on epigenetic mechanisms in adipose tissue that may account for transgenerational dysregulation of adipocyte formation and adipose tissue function.There is increasing evidence that adult-onset disorders, including obesity, may derive fro...

Brief summary: This study investigated adipose tissue cellularity and functionality in more than 400 individuals with early-onset obesity (before the age of 18 years) versus late-onset of obesity (after the age of 18 years) compared to never-obese subjects. Individuals with obesity had increased subcutaneous white adipose tissue amounts resulting from a combination of increased size and numbers of fat cells.Interestingly, individuals with early-onset obe...

Brief Summary: This study created a temporally- and spatially-resolved proteomic atlas of human adipogenesis. It highlights cell restructuring and spatial reorganization of metabolic pathways to optimize cells for lipid accumulation and identifies C19orf12 as a differentiation-induced protein that regulates lipid storage in adipocytes.This study provides a comprehensive and detailed proteomic map that captures the dynamic changes in protein abundance and...