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ey0019.8-1 | Mechanism of the year: neuropeptide substance P regulates aldosterone secretion | ESPEYB19

8.1. The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys

K Cheng , Y Seita , T Moriwaki , K Noshiro , Y Sakata , YS Hwang , T Torigoe , M Saitou , H Tsuchiya , C Iwatani , M Hosaka , T Ohkouchi , H Watari , T Umazume , K Sasaki

Sci Adv. 2022; 8(16): eabn8485. PMID: 35442744https://pubmed.ncbi.nlm.nih.gov/35442744/Brief Summary: This histologic and transcriptomic study of human and primate adrenal tissue samples provides a molecular framework to understand the fetal development of the adrenal gland.The adrenal cortex is the major source of steroid hormones that drive a plethora of critical ph...

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ey0020.4-2 | Sexuality, Fertility and Fertility Optimization in DSD | ESPEYB20

4.2. Generation of functional oocytes from male mice in vitro

K Murakami , N Hamazaki , N Hamada , G Nagamatsu , I Okamoto , H Ohta , Y Nosaka , Y Ishikura , TS Kitajima , Y Semba , Y Kunisaki , F Arai , K Akashi , M Saitou , K Kato , K Hayashi

Brief summary: This in vitro study reports that fully potent oocytes were generated from pluripotent stem cells of the tail of a sexually mature male mouse. These oocytes were able to give rise to offspring after fertilization.A particular challenge in the care of DSD patients in adulthood is the optimization of fertility potential. Fertility outcome is significantly reduced in all types of DSD depending on the underlying etiology as well as the...

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ESPE Yearbook of Paediatric Endocrinology

8.1. The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys

4.2. Generation of functional oocytes from male mice in vitro

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