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ey0017.2-14 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB17

2.14. Gestational diabetes adversely affects pancreatic islet architecture and function in the male rat offspring

P Agarwal , N Brar , TS Morriseau , SM Kereliuk , MA Fonseca , LK Cole , A Jha , B Xiang , KL Hunt , N Seshadri , GM Hatch , CA Doucette , VW Dolinsky

To read the full abstract: Endocrinology. 2019 Aug 1;160(8):19071925. PMID: 31237608Gestational diabetes (GDM) is associated with impaired beta-cell function in the offspring and this leads to increased risk of type 2 diabetes mellitus (1). However, the underlying mechanisms are not well understood. GDM exposure may alter islet gene expression and function in the fetus. Impai...

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ey0021.12-9 | Pregnancy and Youth Onset T2D | ESPEYB21

12.9. DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes

OE Salama , N Hizon , M Del Vecchio , K Kolsun , MA Fonseca , DTS Lin , O Urtatiz , JL MacIsaac , MS Kobor , EAC Sellers , VW Dolinsky , AB Dart , MJ Jones , BA Wicklow

Brief Summary: This cross-sectional analysis showed that DNA methylation (DNAm) patterns differ between youth-onset and adult-onset T2D. In utero exposure to maternal diabetes was linked to these distinct changes. These findings highlight unique molecular pathways disrupted by youth-onset T2D, and suggest potential intervention targets to prevent its health impacts.Comment: Growing evidence suggests that T2D in children and adolescents is essentially dif...

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ESPE Yearbook of Paediatric Endocrinology

2.14. Gestational diabetes adversely affects pancreatic islet architecture and function in the male rat offspring

12.9. DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes

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