ESPE Yearbook of Paediatric Endocrinology

Brief summary: In utero the embryo and the fetus are protected by different mechanisms from too high levels of maternal thyroid hormones after transplacental passage such as deiodination and sulfatation of T4 and T3 in the placenta as well as in the tissues of the unborn child (1,2). Maternal hyperthyroidism and its treatment with anti-thyroid drugs is associated with different congenital malformation. However, so far, it remains unclear, which malformations are linke...