ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This review describes the heterogeneity in type 1 diabetes (T1D), the emerging concept of endotypes, and their impact on T1D prediction, prevention and treatment.Growing evidence supports the existence of heterogeneity in T1D genetic background, pathogenesis, clinical course, susceptibility to complications and response to emerging immunotherapy (1,2). This has led to the concept that T1D is not a single disease; instead there are distinct...

Brief summary: This review article discusses the influence of genetics on type 1 diabetes (T1D), particularly with regard to differences across diverse genetic ancestries, and the development of validated genetic risk scores (GRS) for use various populations. These may contribute to disease prevention and treatment.The autoimmune destruction of pancreatic beta cells is triggered by the interaction of genetic predisposition and environmental factors. T1D ...

To read the full abstract: Diabetes Care. 2018;41:311-317Some researchers assume that the etiology of T1DM is distinct from that of Type 2 diabetes mellitus. T1DM is characterized by autoimmune phenomena leading to the destruction of pancreatic islets and most importantly of beta-cells. Genetic factors are thought to influence the likelihood of autoimmune phenomena developing into overt autoimmune di...