ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0017.5-8 | Translational Highlights | ESPEYB17

5.8. Glucocorticoids decrease longitudinal bone growth in pediatric kidney transplant recipients by stimulating the FGF23/FGFR3 signaling pathway

A Delucchi , L Toro , R Alzamora , V Barrientos , M Gonzalez , R Andaur , P Leon , F Villanueva , M Galindo , F Las Heras , M Montecino , D Moena , A Lazcano , V Pinto , P Salas , ML Reyes , V Mericq , L Michea

To read the full abstract: J Bone Miner Res. 2019;34(10):1851–1861.In brief: In a pediatric kidney transplant cohort, glucocorticoid treatment was independently associated with FGF23 levels. Using in vivo and in vitro rat model systems, blocking of Fgfr signalling rescued glucocorticoid-induced skeletal manifestations.Commentary</em...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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