ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Diabetes Care 2020;43(1):187–95. doi: 10.2337/dc19-0708Short summary: Over 5 years follow-up, bariatric surgery compared with medical treatment resulted in dramatic attenuation of diabetic kidney disease (DKD) in adolescents with T2DM and severe obesity, beyond the impact of improved glycaemic control and weight loss.Comment</em...

Thyroid. 2021;31:202–207. doi: 10.1089/thy.2020.0253.This study describes a new genetic thyroid disease that might be unnoticeable in individuals with normal thyroid synthetic capacity, but may cause harm in all patients who are dependent on levothyroxine substitution such as congenital hypothyroidism, acquired hypothyroidism, or post-thyroidectomy.Three iodothyro...

Psychoneuroendocrinology. 2022; 137: 105604. PMID: 34971856https://pubmed.ncbi.nlm.nih.gov/34971856/Brief Summary: This study evaluated the associations between the amygdala total and sub-region volumes in relation to sex hormones – estradiol and free testosterone – as a function of age and genetic differences in androgen receptor sensitivity in 297 adolescents. It provides new kno...

To read the full abstract: J Clin Endocrinol Metab. 2020; 105(4):1098-111. PMID: 31950148.Classical congenital adrenal hyperplasia (CAH) is characterized by impaired glucocorticoid, and often also mineralocorticoid, secretion and increased adrenal androgen production (1). Given the widespread expression of androgen and glucocorticoid receptors throughout the brain (...

To read the full abstract: J Pediatr 2018;202:143–149.Summary: In a case control study of 30 post-institutionalized youths compared with 90 age- and BMI percentile-matched youths living in the Minneapolis-Saint Paul metropolitan area, early life stress, as reflected by height-stunted growth in institutional care, was associated with cardiovascular and metabolic risk in yout...

J Nurs Res. 2019 Mar 7. DOI: 10.1097/jnr.0000000000000313• This qualitative study evaluated the physical and emotional experiences of 13 adults living with disorders of sexual development (DSD) at a tertiary care center in Nigeria.• Diagnosis of DSD is frequently delayed in LMIC resulting in development of ambiguous physical traits and features.<...

To read the full abstract: Cancer. 2018;124:2220-2227The Brief Coping Orientation to Problem Experience (brief COPE) questionnaire was designed to explore the coping strategies used by individuals in response to stress. It has been used to research various populations with chronic health conditions (1). ‘Betweenness centrality’ is a measure of centrality in a graph based on shortest path...

Brief summary: This cross-sectional study provided evidence regarding the usefulness of serum IGF-1/IGFBP-3 ratio as a marker for the diagnosis of GHD in children.Diagnosis of growth hormone deficiency (GHD) is still challenging, due to the insufficient specificity of GH stimulation tests. Serum IGF-1, IGFBP-3, and their combination have been proposed as an alternative to GH stimulation tests. However, despite relatively high specificity, their validity ...

Brief Summary: This population-based cohort study estimated all-cause and cause-specific mortality in 108,061 individuals with newly diagnosed T2D, (16–50 years of age) compared to 829,946 individuals without T2D. Higher relative risks of mortality in younger individuals with vs. without T2D ranged from 4 to 11, depending on the cause of death.Comment: A decade ago, a Markov-like computer model simulated the life course of a hypothetical cohort of U...

To read the full abstract: Pediatrics 144, number 4, October 2019:e20182984Diagnostic delays in the pediatric emergency department (ED) can lead to unnecessary interventions, prolonged length of hospital and emergency department stay (LOS) and even death. This is especially true in diabetic patients presenting with possible diabetic ketoacidosis (DKA). At one institution, DKA determination time (from arrival to diagnosis) was 86 minutes, and 61%...