ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Development and Psychopathology 2017;29:1517-1538Work in rodents, already some years ago, showed that epigenetic changes can be transmitted trans generations. This study shows that in humans, the simple act of touching during infancy has lifelong consequences on gene expression through epigenetic changes that sustain for at least 4 years. Children who were distresse...

Brief Summary: This cross-sectional analysis showed that DNA methylation (DNAm) patterns differ between youth-onset and adult-onset T2D. In utero exposure to maternal diabetes was linked to these distinct changes. These findings highlight unique molecular pathways disrupted by youth-onset T2D, and suggest potential intervention targets to prevent its health impacts.Comment: Growing evidence suggests that T2D in children and adolescents is essentially dif...