ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This review analysed 15 original studies reporting the effects of radiation therapy (RT) on thyroid gland in childhood cancer survivors (CCS). A relationship between RT dose to the thyroid gland and risk of hypothyroidism could be extrapolated from 8/15 studies. Risk of compensated hypothyroidism increased with RT dose to the thyroid: it was 12%, 25% and 44% at 10, 20 and 30 Gy, respectively. Similarly, the risk of overt hypothyroidism was 4%, 7% and 13% at 10, ...