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14.7. Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs

Tomar A. , Gomez-Velazquez M. , Gerlini R. , Comas-Armangue G. , Makharadze L. , Kolbe T. , Boersma A. , Dahlhoff M. , Burgstaller J.P. , Lassi M. , Darr J. , Toppari J. , Virtanen H. , Kuhnapfel A. , Scholz M. , Landgraf K. , Kiess W. , Vogel M. , Gailus-Durner V. , Fuchs H. , Marschall S. , de Angelis M. Hrabě , Kotaja N. , Korner A. , Teperino R.

Brief Summary:This study in mice and humans shows how paternal overweight at conception affects the metabolism of their offspring. Sperm-borne mt-sncRNAs (mitochondrial encoded or derived small non-coding RNAs) are altered by a 2-week high fat diet (HFD) challenge in mice, likely through specific upregulation of mt-tsRNAs (mitochondrial transfer RNAs) caused by mitochondrial dysfunction. In humans, mt-tsRNAs in spermatozoa correlate with body mass index. Genetically engineered...

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ESPE Yearbook of Paediatric Endocrinology

14.7. Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs

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