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ey0015.11-18 | Prebiotics reduce fat mass | ESPEYB15

11.18 Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity

AC Nicolucci , MP Hume , I Martínez , S Mayengbam , J Walter , RA Reimer

To read the full abstract: Gastroenterology. 2017 Sep;153(3):711-722In adults, prebiotic intake is associated with improvements in satiety, postprandial glucose and insulin concentrations (1). The effect of prebiotic intervention in overweight/obese children has been rarely studied. This clinical trial showed that supplementation with oligofructose-enriched inulin for 16 weeks decreased BM...

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ey0015.2-20 | Placental miRNAs dysregulation in maternal obesity may be involved in mediating growth-promoting effects in offspring of obese mothers | ESPEYB15

Placental miRNAs dysregulation in maternal obesity may be involved in mediating growth-promoting effects in offspring of obese mothers

G Carreras-Badosa , A Bonmatí , FJ Ortega , JM Mercader , M Guindo-Martínez , D Torrents , A Prats-Puig , JM Martinez-Calcerrada , F de Zegher , L Ibáñez , JM Fernandez-Real , A Lopez-Bermejo , J Bassols

To read the full abstract: J Clin Endocrinol Metab. 2017 Jul 1;102(7):2584-2594Maternal obesity and nutrient excess in utero increase the risk of future metabolic diseases. The mechanisms underlying this process are poorly understood, but probably include genetic, epigenetic alterations and changes in fetal nutrient supply. Placenta, and particularly amniotic fluid, is the in utero ...

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ey0015.9-11 | Biologic agents in chronic inflammatory diseases: lights and shadows | ESPEYB15

9.11 Perianal pediatric Crohn disease is associated with a distinct phenotype and greater inflammatory burden

A Assa , M Amitai , ML Greer , DA Castro , RC Kuint , M Martínez-León , I Herman-Sucharska , E Coppenrath , S Anupindi , A Towbin , D Moote , O Konen , LT Pratt , A Griffiths , D Turner , ImageKids Study Group

To read the full abstract: J Pediatr Gastroenterol Nutr. 2017;65:293-298Growth deceleration and impaired pubertal growth spurt are common concerns in patients with early onset inflammatory bowel disease (IBD) (1-2). Previous studies confirmed the efficacy and safety of infliximab, an anti-tumor necrosis factor alpha (TNF-α) antibody, in achieving clinical remission in luminal Crohn&#8...

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ey0015.2-1 | A novel disorder of hyperinsulinaemic hypoglycaemia and polycystic kidneys | ESPEYB15

A novel disorder of hyperinsulinaemic hypoglycaemia and polycystic kidneys

OR Cabezas , SE Flanagan , H Stanescu , E García-Martínez , R Caswell , H Lango-Allen , M Antón-Gamero , J Argente , AM Bussell , A Brandli , C Cheshire , E Crowne , S Dumitriu , R Drynda , JP Hamilton-Shield , W Hayes , A Hofherr , D Iancu , N Issler , C Jefferies , P Jones , M Johnson , A Kesselheim , E Klootwijk , M Koettgen , W Lewis , JM Martos , M Mozere , J Norman , V Patel , A Parrish , C Pérez-Cerdá , J Pozo , SA Rahman , N Sebire , M Tekman , PD Turnpenny , WV Hoff , DHHM Viering , MN Weedon , P Wilson , L Guay-Woodford , R Kleta , K Hussain , S Ellard , D Bockenhauer

To read the full abstract: J Am Soc Nephrol. 2017 Aug;28(8):2529-2539The association of hyperinsulinaemic hypoglycaemia (HH) and polycystic kidneys has not been reported before. Here, the authors studied 17 patients from 11 different families and found that all patients had a combination HH and polycystic kidneys. The HH was mild and some patients required diazoxide therapy. In contrast the poly...

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ESPE Yearbook of Paediatric Endocrinology

11.18 Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity

Placental miRNAs dysregulation in maternal obesity may be involved in mediating growth-promoting effects in offspring of obese mothers

9.11 Perianal pediatric Crohn disease is associated with a distinct phenotype and greater inflammatory burden

A novel disorder of hyperinsulinaemic hypoglycaemia and polycystic kidneys

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