ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This study used chemogenetics and transgenic mouse models to show that glutamatergic neurotransmission in leptin responsive neurons in the premammillary nucleus is required for normal puberty and ovulation.Puberty and the acquisition of reproductive functions result from the reawakening of a complex neuroendocrine machinery eventually leading to the activation of GnRH secretion. Metabolic cues play a crucial role in regulating this system ...