Abstract Search

ey0021.3-1 | Mechanism of the Year | ESPEYB21

3.1. Notch signaling in thyrocytes is essential for adult thyroid function and mammalian homeostasis

Mosteiro Lluc , Thu Thao Nguyen Thi , Hankeova Simona , Alvarez-Sierra Daniel , Reichelt Mike , Vandriel Shannon M , Lai Zijuan , Choudhury Feroza K , Sangaraju Dewakar , Kamath Binita M , Scherl Alexis , Pujol-Borrell Ricardo , Piskol Robert , Siebel Christian W

Brief Summary: This study used single-cell RNA sequencing to analyze mouse and human thyroid tissue. It discovered two distinct subtypes of thyrocytes, termed thyroid follicular cell (TFC) 1 and TFC2. These subtypes were characterized by varying levels of metabolic activity and Notch signaling: TFC1 cells exhibit higher metabolic activity and Notch signaling compared to the more quiescent TFC2 cells.Notch signaling is a crucial pathway involved in cell f...

0 shares

ESPE Yearbook of Paediatric Endocrinology

3.1. Notch signaling in thyrocytes is essential for adult thyroid function and mammalian homeostasis

BiosciAbstracts