ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This longitudinal observational study combined data from the SEARCH (T1D: N=564; T2D: N=149) and TODAY studies (T2D: N=495). Complications were higher in those with childhood onset T2D compared to T1D, with T2D showing 2.5 to 4 times higher rates of microvascular, macrovascular events despite similar diabetes duration. Risk factors for complications differed between T2D and T1D, with mean arterial pressure being a common predictor for both.<p class="abstext"...

Brief Summary: Rare forms of diabetes (‘monogenic diabetes’) are caused by a single rare gene variant, while adult-onset T2D is influenced by thousands of common genetic variants. This study reveals that youth-onset T2D shares some genetic features with both monogenic and typical adult-onset T2D, marked by both common and rare genetic variantsComment: A significant challenge is understanding why the course of T2D in children and teenagers is mo...