ISSN 1662-4009 (online)

ey0021.11-15 | Adipocyte Dysfunction and Obesity Related Comorbidities | ESPEYB21

11.15. A spatiotemporal proteomic map of human adipogenesis

F Klingelhuber , S Frendo-Cumbo , M Omar-Hmeadi , L Massier , P Kakimoto , AJ Taylor , M Couchet , S Ribicic , M Wabitsch , AC Messias , A Iuso , TD Muller , M Ryden , N Mejhert , N Krahmer

Brief Summary: This study created a temporally- and spatially-resolved proteomic atlas of human adipogenesis. It highlights cell restructuring and spatial reorganization of metabolic pathways to optimize cells for lipid accumulation and identifies C19orf12 as a differentiation-induced protein that regulates lipid storage in adipocytes.This study provides a comprehensive and detailed proteomic map that captures the dynamic changes in protein abundance and...