ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This prospective study of 62 children with Central Precocious Puberty (CPP) concluded that measuring unstimulated luteinizing hormone (LH) may be adequate to assess effective pubertal suppression.Pubertal stages, growth velocity and bone age maturation are considered as key clinical markers to evaluate adequate pubertal suppression in patients treated for CPP. Basal LH concentrations levels also seem to be effective1. This study...

J Clin Endocrinol Metab. 2020 Oct 1;105(10):e3660–71. 10.1210/clinem/dgaa479. https://academic.oup.com/jcem/article/105/10/e3660/5879679In brief: This phase 3 multi-centre, open-label, single-arm study explores the efficacy, pharmacokinetics and safety of 6-monthly 45-mg subcutaneous leuprolide acetate in 59 pati...

Pediatr Diabetes. 2018 Apr 19. doi: 10.1111/pedi.12683.According to these authors, earlier studies had shown that children with type 1 diabetes mellitus (T1D) experience mild cognitive alterations compared to healthy age-matched controls. This might develop during the course of the disease and relate to both hypo- and hyperglycemia. Another explanation points to psychosocial factors or common u...